Browsing by Author "Cárdenas, César"

Now showing items 1-10 of 10

    • A phenolic-rich extract from ugni molinae berries reduces abnormal protein aggregation in a cellular model ... 
      Pérez Arancibia, Rodrigo Nicolás; Ordóñez, José Luis; Rivas, Alexis; Pihán, Philippe; Sagredo, Alfredo; Ahumada, Ulises; Barriga, Andrés; Seguel, Ivette; Cárdenas, César; Vidal, René L.; Hetz Flores, Claudio Andres; Delporte Vergara, Carla Luz (Public Library Science, 2021)
      Accumulation of misfolded proteins in the brain is a common hallmark of most age-related neurodegenerative diseases. Previous studies from our group identified the presence of anti-inflammatory and antioxidant compounds ...
    • Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered ... 
      Cárdenas, César; Juretic Díaz, Nevenka Militza; Bevilacqua, Jorge; García, Isaac E.; Figueroa, Reinaldo; Hartley, Ricardo; Taratuto, Ana L.; Gejman, Roger; Riveros, Nora; Molgó, Jordi; Jaimovich Pérez, Enrique (2010)
      Inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) drive calcium signals involved in skeletal muscle excitation-transcription coupling and plasticity; IP3R subtype distribution and downstream events evoked by their ...
    • CD73 ectonucleotidase restrains CD8+T cell metabolic fitness and anti-tumoral activity 
      Briceño Catalán, Pedro Felipe; Rivas Yáñez, Elizabeth Camila; Rosemblatt Bono, Mariana Violeta; Parra Tello, Brian Josué; Farías, Paula; Vargas, Leonardo; Simon Zegers, María Valeska; Cárdenas, César; Lladser, Álvaro; Salazar Onfray, Flavio Andrés; Elorza, Álvaro A.; Rosemblatt Silber, Mario César; Bono Merino, María Rosa; Sauma Mahaluf, Daniela Macarena (Frontiers Media, 2021)
      CD39 and CD73 are ectoenzymes that dephosphorylate ATP into its metabolites; ADP, AMP, and adenosine, and thus are considered instrumental in the development of immunosuppressive microenvironments. We have previously shown ...
    • Depolarization of skeletal muscle cells induces phosphorylation of cAMP response element binding protein ... 
      Cárdenas, César; Müller, Marioly; Jaimovich Pérez, Enrique; Pérez Bravo, Francisco; Buchuk, Diego; Quest, Andrew F. G.; Carrasco Friz, María Angélica (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2004-09-10)
      Membrane depolarization of skeletal muscle cells induces slow inositol trisphosphate-mediated calcium signals that regulate the activity of transcription factors such as the cAMP-response element-binding protein (CREB), ...
    • Directly reprogrammed human neurons to understand age-related energy metabolism impairment and mitochondrial ... 
      Gudenschwager Ruiz, Camila Andrea; Chávez, Isadora; Cárdenas, César; González Billault, Christian Enrique (Hindawi, 2021)
      Brain aging is characterized by several molecular and cellular changes grouped as the hallmarks or pillars of aging, including organelle dysfunction, metabolic and nutrition-sensor changes, stem cell attrition, and ...
    • Inhibition of InsP3R with xestospongin B reduces mitochondrial respiration and induces selective cell death ... 
      Cruz, Pablo; Ahumada Castro, Ulises Jonas; Bustos, Galdo; Molgó, Jordi; Sauma Mahaluf, Daniela Macarena; Lovy, Alenka; Cárdenas, César (MDPI, 2021)
      T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy whose chemoresistance and relapse persist as a problem despite significant advances in its chemotherapeutic treatments. Mitochondrial ...
    • Insulin-like growth factor-1 induces an inositol 1,4,5-trisphosphate-dependent increase in nuclear and ... 
      Ibarra, Cristián; Estrada Hormazábal, Manuel; Carrasco Mujica, Loreto; Chiong Lay, Mario; Liberona Leppe, José; Cárdenas, César; Díaz Araya, Guillermo; Jaimovich Pérez, Enrique; Lavandero González, Sergio (Amer Biochemistry Molecular Biology, 2004-02-27)
      In the heart, insulin-like growth factor-1 (IGF-1) is a pro-hypertrophic and anti-apoptotic peptide. In cultured rat cardiomyocytes, IGF-1 induced a fast and transient increase in Ca-i(2+) levels apparent both in the nucleus ...
    • Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response ... 
      Cárdenas, César; Liberona Leppe, José; Molgó, Jordi; Colasante, Cesare; Mignery, Gregory; Jaimovich Pérez, Enrique (COMPANY OF BIOLOGISTS LTD, 2005-07-15)
      Several lines of evidence indicate that increases in nuclear Ca2+ have specific biological effects that differ from those of cytosolic Ca2+, suggesting that they occur independently. The mechanisms involved in controlling ...
    • Single-channel recording of inositol trisphosphate receptor in the isolated nucleus of a muscle cell line 
      Kusnier, Carlos; Cárdenas, César; Hidalgo Tapia, Jorge; Jaimovich Pérez, Enrique (SOCIEDAD BIOLGIA CHILE, 2006)
      Nuclear calcium appears to have an important role in the regulation of gene expression in many cells, but the mechanisms involved in controlling nuclear Ca2+ signaling are controversial and still poorly understood. We have ...
    • Xestospongin B, a competitive inhibitor of IP3-mediated Ca2+ signalling in cultured rat myotubes, isolated ... 
      Jaimovich Pérez, Enrique; Mattei, César; Liberona Leppe, José; Cárdenas, César; Estrada Hormazábal, Manuel; Barbier, Julien; Debitus, Cécile; Laurent, Dominique; Molgó, Jordi (ELSEVIER SCIENCE BV, 2005-04-11)
      Xestospongin B, a macrocyclic bis-1-oxaquinolizidine alkaloid extracted from the marine sponge Xestospongia exigua, was highly purified and tested for its ability to block inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ ...